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Sarcoidosis CT images reveal bilateral hilar lymphadenopathy, usually symmetrical. Central lymph nodes along the bronchi enlarge first, followed by nodes surrounding the pulmonary artery. The absence of caseating granulomas or neoplastic cells is characteristic of sarcoidosis. Imaging Findings: Unveiling the Hidden Secrets of Your Lungs Picture this: you’re feeling a little under the weather, with…

Sarcoidosis and pulmonary fibrosis are closely related entities that affect the lungs. Sarcoidosis is an inflammatory disease that can cause granulomas, or small collections of inflammatory cells, to form in the lungs and other organs. Pulmonary fibrosis is a condition in which the tissue of the lungs becomes scarred and thickened, making it difficult to…

Sarcoidosis, an inflammatory disease affecting multiple organs, can present with skin manifestations. Tattoos in individuals with sarcoidosis may pose risks such as inflammation and keloids. Consider alternative body art options like henna or temporary tattoos for safer self-expression. Understanding Sarcoidosis: A Guide for Everyone Sarcoidosis is a puzzling condition that can strike people of all…

Sarcoidosis is a granulomatous disease that can lead to hypercalcemia. The formation of granulomas releases cytokines that stimulate osteoclasts, leading to increased bone resorption and calcium release into the bloodstream. Autoimmune mechanisms may also contribute to hypercalcemia by activating T cells that produce cytokines that stimulate osteoclasts. Other entities related to hypercalcemia in sarcoidosis include…

Sarcoidosis is a systemic inflammatory disease characterized by the formation of noncaseating granulomas in various organs. Lacrimal gland involvement occurs in approximately 5% of sarcoidosis patients, leading to swelling, which can cause dryness, pain, and vision problems. Diagnosis involves biopsy or imaging techniques. Treatment options include corticosteroids, immunosuppressive drugs, and topical lubrication. Associated syndromes include…

Sarcoidosis is a systemic inflammatory disorder of unknown cause that can affect multiple organs and systems, including the lungs, lymph nodes, skin, joints, eyes, and heart. Diagnosis involves imaging techniques like chest X-ray and CT scans, biopsies to examine affected tissues, and blood tests to detect specific biomarkers. Treatment options depend on the severity and…

Sarcoidosis is a systemic granulomatous disease characterized by the formation of non-caseating granulomas in various organs, including the liver. Liver involvement is common, affecting up to 70% of patients, and can range from asymptomatic to severe, potentially leading to fibrosis, hepatic failure, and hepatic encephalopathy. Diagnosis is confirmed via biopsy, while serum markers, such as…

Sarcoidosis ocular manifestations encompass inflammatory (e.g., uveitis, episcleritis), vascular (e.g., retinal vasculitis), and posterior segment (e.g., choroiditis) involvement. These manifestations can range from mild to severe, with potential complications such as vision loss. Differential diagnosis and management require a comprehensive approach, including diagnostic tests and treatment modalities ranging from medications to surgical interventions. Ocular involvement…

Vitamin D deficiency is common in sarcoidosis and linked to disease severity. Vitamin D acts as an immunomodulator, affecting granulomatous inflammation and immune cell function in sarcoidosis. Supplementation with vitamin D has shown promise in reducing disease activity and improving outcomes. Clinical trials are investigating the optimal dosage and duration of treatment. Understanding the role…

Sarcoidosis, a chronic inflammatory disease, affects calcium metabolism. Its impact stems from its interference with calcium homeostasis mechanisms. Altered calcium levels can lead to complications like hypercalcemia or hypocalcemia. Diagnostic markers such as serum calcium and parathyroid hormone aid in assessing calcium balance. Vitamin D metabolism and hormonal regulation are also affected in sarcoidosis. Clinical…

Hypercalcemia in sarcoidosis occurs due to excessive release of 1,25-dihydroxyvitamin D by activated macrophages and granulomatous cells. It leads to increased intestinal calcium absorption and bone resorption, resulting in hypercalciuria and subsequent kidney damage. Clinical manifestations include fatigue, muscle weakness, dehydration, and neurological symptoms. Radiographic findings may reveal pulmonary infiltrates, lymph node enlargement, bone lesions,…

Sarcoidosis is an inflammatory disease characterized by the formation of granulomas, with vitamin D deficiency being a potential risk factor. Vitamin D, essential for calcium absorption and bone health, also plays a crucial role in immune function. Studies indicate a relationship between vitamin D deficiency and sarcoidosis, and supplementation has shown promise in improving disease…