Aspirin: Cox Inhibition For Clot Prevention
Aspirin exerts its effects by irreversibly inhibiting cyclooxygenase (COX) enzymes, specifically COX-1, in platelets. COX enzymes play a crucial role in the synthesis of thromboxane A2 (TXA2), a pro-aggregatory lipid mediator that promotes platelet activation and clot formation. By inhibiting COX-1, aspirin blocks the production of TXA2, leading to decreased platelet aggregation and a reduced…