Dengue fever is a viral infection transmitted by mosquitoes that can cause a range of symptoms from mild fever to severe hemorrhagic fever. Platelet count is a measure of the number of platelets in the blood, which are important for blood clotting. In dengue fever, platelet count can drop significantly, increasing the risk of bleeding…

Neonatal thrombocytopenia, defined as a platelet count below 150,000/µL in newborns, is a prevalent and potentially life-threatening condition. It can arise from various factors, including immune disorders like immune thrombocytopenia purpura (ITP) and infections like sepsis. Neonatal thrombocytopenia intrinsically affects platelet production and function, leading to impaired hemostasis and increased bleeding risks. Early identification and…

Teg platelet mapping is a laboratory test that uses a device called a TEG (thrombelastography) analyzer to measure the function of a patient’s platelets, which play a crucial role in blood clotting. The test provides a comprehensive assessment of platelet activity, including platelet count, platelet aggregation, and clot stability, which can help diagnose bleeding disorders…

High platelet count on Plavix, a medication used to prevent blood clots, can indicate an increased risk of developing clots. Conditions like thrombocytosis and essential thrombocythemia, as well as medications like clopidogrel and aspirin, can impact platelet function and blood clotting. Procedures such as arterial stenting and myocardial infarction also contribute to clot formation. Risk…

Platelet count, influenced by various factors including medical conditions and medications, plays a crucial role in preoperative management, intraoperative hemostasis, and postoperative platelet management during surgery. Thrombocytopenia and thrombocytosis can pose challenges, necessitating transfusion to prevent excessive bleeding. The anesthesiologist monitors blood loss while the hematologist provides specialized care. Diagnostic tests like CBC and platelet…

Platelet-rich plasma (PRP) ovaries refer to a medical procedure where PRP, a concentrated source of growth factors, is injected into the ovaries. This technique aims to improve ovarian function and rejuvenate aging ovaries, potentially enhancing fertility and reducing symptoms associated with ovarian decline. PRP contains various growth factors that promote cell growth, angiogenesis, and tissue…

Thrombocytopenia, a condition characterized by low platelet counts, is commonly associated with advanced HIV disease. The presence of HIV infection increases the risk of developing thrombocytopenia, particularly in individuals with low CD4 cell counts. The underlying immune dysregulation caused by HIV can lead to thrombocytopenia, impairing platelet production or increasing platelet destruction. Management of thrombocytopenia…

Normal platelet count in newborns ranges from 150,000 to 400,000/μL, with variations based on gestational age and health status. Factors influencing platelet counts include maternal platelet count, maternal health, and neonatal infections. Neonatal thrombocytopenia (low platelet count) can be caused by immune disorders, infections, congenital disorders, or consumptive processes, while thrombocytosis (high platelet count) may…

Sticky platelet syndrome, a rare platelet adhesion disorder, arises from genetic mutations affecting the glycoprotein (GP) Ib-IX-V complex on platelets. These mutations impair platelet adhesion to von Willebrand factor, resulting in prolonged bleeding times and an increased risk of bleeding episodes. Diagnosis involves platelet aggregation studies, immunologic assays, and genetic testing. Treatment typically includes platelet…

A high platelet count in newborns, known as thrombocytosis, occurs when the blood contains an elevated number of platelets. It is commonly seen in premature infants due to their immature platelet production and can also result from birth trauma, infections, genetic disorders (e.g., hereditary thrombocytosis, Down syndrome), and acquired conditions (e.g., sepsis, respiratory distress syndrome)….

Platelets, produced in bone marrow by megakaryocytes, have a lifespan of 8-11 days. Thrombopoietin regulates their production, aided by Interleukin-11 and Interleukin-6. Imbalances in platelet count lead to thrombocytopenia (low count) or thrombocytosis (high count). ITP is an autoimmune disorder causing thrombocytopenia. Bleeding disorders occur with platelet dysfunction, while thrombotic events result from excessive clotting….

Dengue virus infection can lead to severe thrombocytopenia, a condition characterized by a sharp drop in platelet count. Platelets are essential blood cells involved in blood clotting. Dengue virus targets and infects platelets, impairing their function and reducing their lifespan. This dysfunction can manifest as bleeding disorders, including skin hemorrhages, mucosal bleeding, and gastrointestinal bleeding….